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dss plus epptb  (MedChemExpress)
93
MedChemExpress dss plus epptb
Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
Dss Plus Epptb, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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w v dextran sulphate sodium dss mp biomedicals  (Valiant Co Ltd)
96
Valiant Co Ltd w v dextran sulphate sodium dss mp biomedicals
Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
W V Dextran Sulphate Sodium Dss Mp Biomedicals, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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w v dextran sodium sulfate dss mw 36 50 kda mp biomedicals  (Valiant Co Ltd)
94
Valiant Co Ltd w v dextran sodium sulfate dss mw 36 50 kda mp biomedicals
Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
W V Dextran Sodium Sulfate Dss Mw 36 50 Kda Mp Biomedicals, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dss  (Valiant Co Ltd)
97
Valiant Co Ltd dss
Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
Dss, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dextran sodium sulfate dss  (Valiant Co Ltd)
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Valiant Co Ltd dextran sodium sulfate dss
Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
Dextran Sodium Sulfate Dss, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dss administration  (MedChemExpress)
94
MedChemExpress dss administration
Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
Dss Administration, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dextran sulfate sodium dss  (Valiant Co Ltd)
97
Valiant Co Ltd dextran sulfate sodium dss
Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
Dextran Sulfate Sodium Dss, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dextran sulfate sodium dss solution  (Valiant Co Ltd)
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Valiant Co Ltd dextran sulfate sodium dss solution
Fecal Tryp, PEA, and Tyr in UC and <t>DSS-colitis</t> mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with <t>EPPTB</t> (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.
Dextran Sulfate Sodium Dss Solution, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.

Journal: Biochemistry and Biophysics Reports

Article Title: The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition

doi: 10.1016/j.bbrep.2025.102432

Figure Lengend Snippet: Fecal Tryp, PEA, and Tyr in UC and DSS-colitis mice, and TAAR1 inhibition attenuates their 5-HT release from QGP-1 cells and mouse ex vivo colonic tissues. (A) Fecal levels of Tryp, PEA, and Tyr in healthy control (n = 15) and UC patients (n = 20). (B) Fecal levels of Tryp, PEA, and Tyr in Control (Con) mice and DSS-induced colitis mice (n = 12). Student's t-test were used to determine differences between two groups in Data A and B. (C) The 5-HT levels in QGP-1 cells following 24-h treatments with PEA, Tryp, or Tyr (20 μM) alone, and each amine in combination with EPPTB (20 μM) (n = 3). (D) The 5-HT levels in mouse ex vivo colonic tissues following 2-h treatments with PEA, Tryp, or Tyr (50 μM) alone, or each amine in combination with EPPTB (50 μM) (n = 4). One-way ANOVA followed by Tukey's multiple comparisons test was used to determine differences between two groups in Data C and D. Data are presented as means ± SD. * P < 0.05, ** P < 0.01, ***P < 0.001 and **** P < 0.0001.

Article Snippet: Following one cycle of DSS administration, all mice developed consistent colitis and were randomly allocated into two groups (n = 6 per group): DSS alone, and DSS plus EPPTB (10 mg/kg; MedChemExpress, New Jersey, USA).

Techniques: Inhibition, Ex Vivo, Control